High School

What combination of ester and bromo-Grignard reagent could you use to prepare the following tertiary alcohol?

A. Methyl ester and bromo-Grignard reagent
B. Ethyl ester and bromo-Grignard reagent
C. Propyl ester and bromo-Grignard reagent
D. Butyl ester and bromo-Grignard reagent

Answer :

Final answer:

To synthesize a tertiary alcohol, an ethyl ester and a bromo-grignard reagent such as 2-bromopropane can be used. The resulting product will be a tertiary alcohol after a Grignard reaction and subsequent acid work-up.

Explanation:

In order to prepare a tertiary alcohol, one must consider the structure of the targeted alcohol and the precursors that would be required for its synthesis using a Grignard reaction. A Grignard reagent reacts with an ester to produce a tertiary alcohol after two additions of the Grignard reagent and a final acid work-up. For instance, ethyl ester and bromo-grignard reagent can be used.

The bromo-grignard reagent would be a compound like 2-bromopropane which, when reacted with ethyl ester such as ethyl acetate, will result in a tertiary alcohol after the necessary reaction steps. To synthesize a tertiary alcohol, an ethyl ester and a bromo-grignard reagent such as 2-bromopropane can be used. The resulting product will be a tertiary alcohol after a Grignard reaction and subsequent acid work-up.

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