Answer :
Final answer:
The Direct Activation Pathway is known as the Extrinsic Pathway. It is a quick response system that initiates blood clotting through the release of factor III from damaged extravascular cells, activating further factors leading to the common pathway, and ends with clot formation.
Explanation:
The Direct Activation Pathway is also known as the Extrinsic Pathway. The extrinsic pathway, also termed the tissue factor pathway, is the quicker responding pathway that begins with the release of factor III (thromboplastin) when extravascular cells are damaged, as might occur in a traumatic injury. This pathway involves a sequence where factor VII (proconvertin) gets activated, leading to the formation of an enzyme complex which then activates factor X (Stuart-Prower factor), proceeding to the common pathway and culminating in the formation of a blood clot.
The intrinsic pathway, on the other hand, is longer and initiated by the Hageman factor (factor XII) which is intrinsic to the bloodstream and activated by internal factors or exposure to foreign materials. Both pathways converge on the common pathway where factor X activates thrombin, which then converts fibrinogen into insoluble fibrin to create a clot.
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