Answer :
Final answer:
The C5 convertase of the alternative pathway is formed by the binding of the C3bBb complex to C3b, resulting in the formation of the C3bBbC3b complex.
Explanation:
The alternative pathway is a part of the complement system, which is involved in the immune response against foreign substances. The alternative pathway convertases are enzymes that play a crucial role in the amplification and regulation of the complement cascade.
The C3 convertase of the alternative pathway is formed by the cleavage of C3 into C3a and C3b. C3b then binds to factor B, forming the C3bB complex. This complex is stabilized by factor D, resulting in the formation of the C3bBb complex, which is the active form of C3 convertase.
To generate the C5 convertase of the alternative pathway, the C3bBb complex needs to bind to C3b, forming the C3bBbC3b complex. This complex can then cleave C5 into C5a and C5b, initiating the formation of the membrane attack complex (MAC) and the subsequent lysis of the target cell.
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