High School

A 23-year-old man comes to the office due to a left-sided jaw mass that has rapidly enlarged over the past several weeks. The patient is an immigrant from East Africa. He has no known medical problems and takes no medications. Temperature is 37.1°C (98.8°F). Physical examination shows a large left-sided tumor on his jaw with associated lymphadenopathy but no erythema or warmth. The rest of the examination is unremarkable. HIV testing is negative. The lesion is biopsied, and numerous mitotic figures and apoptotic bodies are observed on histopathologic examination.

Which genetic feature is most likely to be present in the abnormal tissue?

Answer :

Final answer:

The most likely genetic feature present in the abnormal tissue is a translocation involving the MYC gene.

Explanation:

The presence of numerous mitotic figures and apoptotic bodies on histopathologic examination suggests a highly proliferative and rapidly growing tumor. In a 23-year-old man with a left-sided jaw mass that has rapidly enlarged, the most likely genetic feature present in the abnormal tissue is a translocation involving the MYC gene. Translocation involving the MYC gene is commonly seen in Burkitt lymphoma, which is highly associated with Epstein-Barr virus infection.

Learn more about Burkitt lymphoma here:

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