Answer :
Final answer:
The dopaminergic pathway associated with Parkinson's disease is the Nigrostriatal pathway. This pathway relies on dopamine release from neurons in the substantia nigra pars compacta to the striatum, crucial for maintaining a balance between motion and rest. A deficiency leads to Parkinson's disease symptoms.
Explanation:
The dopaminergic pathway associated with Parkinson's disease is the Nigrostriatal pathway. Parkinson's disease results from the death of neurons in the substantia nigra pars compacta. These neurons usually release dopamine into the striatum, a critical part of the dopaminergic pathway, leading to a healthy balance between motion and rest.
When these neurons are significantly depleted, there's insufficient activation of the direct pathway, and the indirect pathway becomes dominant. This skewed balance leads to the reduction in voluntary movement, a characteristic of Parkinson's disease.
To better illustrate, consider a student in a lecture. If the substantia nigra pars compacta is silent (as would be the case in Parkinson's disease), it indicates a passive state, meaning the student is less likely to get up and walk around. Conversely, when the substantia nigra pars compacta is active, it signals an active state, hence, promoting movement.
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