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------------------------------------------------ What are the zones of the metaphysis, and what is happening in each zone?

A. Zone of cartilage formation, zone of muscle attachment, zone of joint development

B. Zone of bone resorption, zone of cartilage proliferation, zone of bone deposition

C. Zone of cell division, zone of cell hypertrophy, zone of cell calcification

D. Zone of blood vessel invasion, zone of nutrient absorption, zone of mineralization

The zones of metaphysis in long bones, where growth and development occur, are described as follows: c) Zone of cell division, zone of cell hypertrophy, zone of cell calcification

Explanation:

The metaphysis of a long bone has three significant zones: the zone of cell division, the zone of cell hypertrophy, and the zone of cell calcification.

The zone of cell division or the proliferative zone is a region of the epiphyseal plate that makes new chondrocytes to replace those that die at the diaphyseal end, thus contributing to the longitudinal growth of the epiphyseal plate.

The zone of cell hypertrophy contains mature and larger chondrocytes which, as cellular division in the proliferative zone takes place, gets pushed away from the epiphysis plate and closer to the diaphyseal end. Zone of cell calcification, being the zone closest to the diaphysis with matrix around it calcifying, has chondrocytes that are mostly dead.

Capillaries and osteoblasts penetrate this zone from the diaphysis, and the osteoblasts secrete bone tissue on the remaining calcified cartilage, hence connecting the epiphyseal plate to the diaphysis.

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