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------------------------------------------------ The birth weight of baby Josephine was 6 lbs and 12 oz. At one year, baby Josephine is expected to weigh:

1) 18 lbs 1 oz
2) 16 lbs 2 oz
3) 20 lbs 4 oz
4) 12 lbs 2 oz

Based on typical growth patterns, baby Josephine is expected to triple her birth weight by one year, therefore the most accurate estimate would be option 3, which is 20 lbs 4 oz. The correct option is 3.

An infant's expected weight gain can be calculated by understanding the typical growth patterns described in health and development literature. For a baby like Josephine with a birth weight of 6 lbs 12 oz, it is typical for an infant to triple their birth weight by one year. Given that on average, an infant doubles in weight by 4 months and triples by one year, Josephine's expected weight at one year would be approximately 20 lbs 4 oz. This aligns with historical references and modern growth standards.

Hence, among the options given, the best estimate for baby Josephine's weight at one year would be 20 lbs 4 oz (Option 3).