Order: Trimethoprim/sulfamethoxazole 100/20 mg every 12 hours for a child who weighs 15 kg. The recommended daily dosage is 8 mg/kg/day every 12 hours. Trimethoprim/Sulfamethoxazole is available as 200/40 mg per 5 mL.

A) Child's weight: 15 kg

B) Recommended daily dosage:
\[ 8 \, \text{mg/kg/day} \times 15 \, \text{kg} = 120 \, \text{mg/day} \]

C) Recommended single dosage:
\[ \frac{120 \, \text{mg}}{2} = 60 \, \text{mg/dose} \]

D) Is the dosage ordered safe?
No, the order is for 100/20 mg per dose, which exceeds the recommended single dose of 60 mg.

E) If the dosage ordered is safe, calculate the dose:
The order is not safe, as it results in overdosing.

The prescribed single dosage Calculation of Trimethoprim/Sulfamethoxazole for the 15 kg child is too high and poses risks of overdosing. The recommended dosage based on the child's weight should be 60 mg per dose. This medication should be administered with caution due to its impact on drug metabolism and potential side effects.

The correct option is: d)

Explanation:

The calculation of the dosage of medication, such as Trimethoprim/Sulfamethoxazole, is of utmost importance to ensure the safety and effectiveness of the treatment. In this particular case, the ordered single dosage of 100/20 mg is indeed excessive when compared with the recommended dosage calculated on the basis of the child's weight (8 mg/kg/day). For a child weighing 15 kg, the recommended dosage is 120 mg per day, or 60 mg per dose if administered twice daily (q12h).

Therefore, the prescribed dosage is unsafe for the child due to potential overdosing. Overdosing could lead to serious side effects, an example of which includes reduced drug metabolism that could result in increased drug levels and potential toxicity.

Trimethoprim/Sulfamethoxazole is a synthetic antimicrobial compound used commonly to treat infections. Its dosage should be carefully considered especially in children and during pregnancy due to its impact on fetal development.

The correct option is: d)

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