High School

How many times can a carboxylic acid derivative reaction with an organometallic compound such as a Grignard reagent?

Answer :

carboxylic acid derivative can initially react once with a Grignard reagent, further reactions may occur if excess Grignard reagent is present.

Carboxylic acid derivatives, such as acid chlorides, acid anhydrides, esters, and amides, can react with organometallic compounds like Grignard reagents to form ketones, aldehydes, alcohols, or tertiary amines, depending on the specific reaction conditions.

In general, carboxylic acid derivatives can react with Grignard reagents once to form a ketone or an alcohol, depending on the specific conditions. However, the product obtained may further react with excess Grignard reagent if present, leading to the formation of a tertiary alcohol or a hydrocarbon, depending on the reactivity of the carbonyl compound and the Grignard reagent.