Answer :
Final answer:
The cell cycle is regulated by regulatory proteins that control checkpoints where the cycle can be paused or advanced. These mechanisms prevent uncontrolled cell division, repairing DNA damage and promote proper cell functioning. Any malfunction in regulation could potentially lead to cancer.
Explanation:
Regulation of the Cell Cycle
The cell cycle is regulated by internal and external mechanisms that ensure the proper sequencing and timing of cell division. Regulation is critical to prevent uncontrolled cell division, which can lead to conditions such as cancer. Regulatory proteins play a key role in this process, controlling the cell cycle at several checkpoints. These checkpoints are located at transition points in the cycle, particularly at the end of G₁, the G₂/M transition, and during metaphase.
Positive regulator molecules signal the cell to proceed through the checkpoints, allowing the cycle to advance to the next phase. In contrast, negative regulators monitor conditions and can halt the cycle if requirements are not met, acting as a safety mechanism. Cells may enter a state of dormancy, known as G₀, if they do not pass the G₁ checkpoint, or to stop cycling once they have fully differentiated.
Furthermore, damage to DNA triggers repair mechanisms before the cell can continue dividing. This is one way in which the cell cycle is paused. A malfunction in these regulatory systems could lead to issues such as the transformation of normal cells into cancer cells, highlighting the importance of precise control over cell division.
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