High School

Do Grignard reagents react with ethers?

Please list the functional groups that react with Grignard reagents and those that do not.

Answer :

Final answer:

Grignard reagents can react with ethers, resulting in the formation of alcohols. Functional groups that contain carbon-oxygen double bonds, such as aldehydes, ketones, and esters, are reactive with Grignard reagents. However, functional groups like alcohols and carboxylic acids do not typically react with Grignard reagents.

Explanation:

Grignard reagents, which are organometallic compounds, can react with ethers. The reaction between a Grignard reagent and an ether results in the formation of an alcohol. This reaction is known as the Williamson ether synthesis.

Some examples of functional groups that react with Grignard reagents include aldehydes, ketones, and esters. These functional groups contain carbon-oxygen double bonds that can be broken during the reaction with a Grignard reagent.


On the other hand, functional groups such as alcohols and carboxylic acids do not typically undergo reactions with Grignard reagents. This is because these functional groups already contain carbon-oxygen bonds that are relatively stable and do not easily react with Grignard reagents.

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