Answer :
Final answer:
Pyruvate Dehydrogenase is a rate limiting enzyme in the glycolysis and citric acid cycle. It catalyzes the conversion of pyruvate to acetyl-CoA. If this enzyme is inhibited or unavailable, the pathway would cease to function.
Explanation:
One example of a rate limiting enzyme from a pathway is Pyruvate Dehydrogenase in the pathway of glycolysis and citric acid cycle. This enzyme catalyzes the conversion of pyruvate to acetyl-CoA, which is a critical step linking the glycolytic pathway to the citric acid cycle.
a- The whole reaction: Pyruvate + Coenzyme A + NAD+ -> Acetyl-CoA + CO2 + NADH.
b- In the absence of this enzyme, the pathway would cease to function. If Pyruvate Dehydrogenase is inhibited or not available, pyruvate cannot be converted to acetyl-CoA, effectively stopping its entry into citric acid cycle thereby limiting the rate of the pathway.
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