Answer :
Any substance that contains acidic functional groups would not work as a Grignard reagent.
The Grignard reaction can be basically categorized as an organometallic chemical reaction in which there is a Grignard reagent which is the alkyl, vinyl, allyl, or aryl-magnesium halides is reacted with particular carbonyl group in an aldehyde or in a ketone. This reaction is crucial particularly for the formation of the carbon–carbon bonds.
Grignard reagents that are used in this reaction are basically strong nucleophiles and possess the ability to form carbon-carbon bonds, making them similar to the organolithium reagents. Grignard reagents cannot be made from substances having acidic functional groups present in the halogen compound. The Grignard reagent will get destroyed by the reaction with acidic hydrogen atoms of water, phenols, alcohols, or carboxylic acid groups.
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