Answer :
The significant lesson that the resolution of the nullification crisis demonstrated is: when a state defied the federal government, the problem could be resolved.
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One should not ignore any typos or irrelevant parts of the question. One should also use the terms present in the question in the answer. Additionally, it is important to provide a well-reasoned and supported answer.
As for the question at hand, the significant lesson that the resolution of the nullification crisis demonstrated is that when a state defied the federal government, the problem could be resolved. Thus, the answer is: when a state defied the federal government, the problem could be resolved.
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