High School

Suppose a geneticist uses a three-point test cross to map three linked Drosophila recessive mutations: s, w, and b. Which of the following represents the expected genetic outcomes?

A. ss ww bb
B. ss Ww Bb
C. Ss Ww Bb
D. Ss Ww bb

Answer :

Final answer:

In a three-point test cross involving linked genes in Drosophila, the expected genetic outcomes would predominantly show the parental genotypes, much more so than recombinant genotypes. However, with unlinked genes, the expected genetic outcomes would follow a Mendelian ratio.

Explanation:

The question is focused on the concept of genetic mapping and inheritance patterns in Drosophila, a common model organism used in genetic studies. A three-point test cross is used by geneticists to determine the order and distance of genes on a chromosome. When dealing with linked genes, the expected genetic outcomes in offspring can differ significantly from those involving unlinked genes, which segregate independently according to Mendelian genetics.

In cases where genes are linked, as with the s, w, and b genes in Drosophila, the test cross with flies of genotype ss ww bb would typically yield progeny that primarily show the parental genotype, with fewer recombinant genotypes due to crossing over. However, if the genes are not linked, the genotype ratio of the offspring will follow the Mendelian 9:3:3:1 ratio for two different traits assuming each gene assort independently.

In a test cross of an F1 heterozygote with a homozygous recessive individual (ss rr), with linkage we expect more parental type offspring and with unlinked genes, we expect a 1:1:1:1 ratio of offspring genotypes. Understanding these concepts is key in genetic crosses and determining the genetic map of an organism.

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