Answer :
Regarding the SAR of curare, the following groups essential for activity is B. ester group.
Curare is a natural toxin found in certain plants, and it acts as a neuromuscular blocking agent by blocking the transmission of nerve impulses to the muscles. The ester group in curare plays a crucial role in its activity because it helps to stabilize the molecule and enhance its binding affinity to its target receptor. The ester group is a functional group that consists of a carbonyl group bonded to an oxygen atom, which is in turn bonded to an alkyl or aryl group. This group allows curare to interact with specific receptors in the body, such as the acetylcholine receptor at the neuromuscular junction.
By binding to this receptor, curare prevents the transmission of nerve signals and leads to muscle paralysis. In summary, the ester group is essential for the activity of curare because it helps stabilize the molecule and enhances its binding affinity to its target receptor. This enables curare to block nerve impulses and induce muscle paralysis. SO the correct answer is B. ester group.
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