High School

Rearrange and complete the following chemical reactions step by step:

1. **Reaction 1: Formation of Grignard Reagent**

- Reactant: CH3CH2−Br
- Reagent: Mg in ether

Result: Formation of the Grignard reagent CH3CH2−MgBr.

2. **Reaction 2: Reaction with Ethylene Oxide**

- Grignard Reagent: CH3CH2−MgBr
- Reagent: Ethylene oxide in ether

Result: Addition of ethylene oxide to the Grignard reagent.

3. **Reaction 3: Reduction with Lithium Aluminum Hydride**

- Product from Reaction 2
- Reagent: (1) LiAlH4

Result: Reduction of the intermediate formed in Reaction 2.

4. **Reaction 4: Protection of Alcohol**

- Alcohol from Reaction 3
- Reagent: TsCl in Pyridine

Result: Formation of the tosylate, protecting the alcohol group.

5. **Reaction 5: Oxidation with TEMPO and NaOCl**

- Tosylate from Reaction 4
- Reagent: TEMPO and NaOCl

Result: Oxidation of the alcohol group to form the final product.

Note: This sequence illustrates a general multi-step synthesis involving formation, reaction, reduction, protection, and oxidation processes. Adjust specific reagents and conditions as necessary for actual laboratory practice.

Answer :

The question involves multistep organic synthesis, using a variety of reagents, from alkyl halides to ethylene oxide, LiAlH4, TsCl, Pyridine, TEMPO, NaOCl - for what seems to be a Grignard reaction, reduction reactions and oxidation reactions.

The question seems to be related to a multistep synthesis reaction in organic chemistry, involving compounds such as alkyl halides, magnesium, ethylene oxide, and various reagents like LiAlH4, TsCl, Pyridine, TEMPO, NaOCl, and others.

In the first segment of the reaction, an alkyl halide (CH3CH2Br) reacts with magnesium in an ether solvent to form a Grignard reagent via a mechanism that involves electron transfer. The product then reacts with ethylene oxide. The reaction is then followed by acid (H3O+) treatment. LiAlH4 is then used as a reducing agent. Following this, TsCl Pyridine is used – pyridine serving as a base and TsCl as a tosylating agent facilitating the substitution reaction. The final treatment involves TEMPO, and then NaOCl, which acts as an oxidizing agent, delivering the final product of the synthesis.

Please note that without a clear presentation of the question, and without knowledge of the specific end product desired, it's difficult to detail the exact progression of these reactions or to be certain of the explanation provided.

Learn more about Multistep Organic Synthesis here:

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