Answer :
Answer : The retrosynthetic analysis of the secondary alcohol formed by the reaction of the Grignard reagent with a ketone can be broken down into the following steps: Deprotonation of the alcohol, addition of Grignard reagent, and formation of a ketone.
Explanation : Retrosynthetic analysis is a technique that is used to design organic synthesis starting from the target molecule by working backward to the starting material or by breaking it down into simpler precursors. Here's the retrosynthetic analysis of the given alcohol which is secondary and formed by reaction of the Grignard reagent with a ketone.
The retrosynthetic analysis of a secondary alcohol formed by the reaction of the Grignard reagent with a ketone can be broken down into the following steps:
Step 1: Deprotonation of the alcohol
This step involves the removal of the proton attached to the oxygen atom of the alcohol.
Step 2: Addition of Grignard reagent
Once the proton is removed, the alcohol would be transformed into an alkoxide ion which will react with the Grignard reagent. The Grignard reagent is added to the alkoxide ion to form a tertiary alcohol.
Step 3: Formation of a ketone
The tertiary alcohol that was formed in step 2 can be broken down into a ketone.
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