College

Part B

Why do you think rheumatoid arthritis is often a degenerative disease?

Answer :

Final answer:

Rheumatoid arthritis is considered a degenerative disease due to the chronic inflammation it causes, leading to joint damage over time. The immune system's attack on healthy joint tissue results in progressive breakdown of cartilage and bone structures. This process can lead to significant pain and reduced mobility in affected individuals.


Explanation:

Why is Rheumatoid Arthritis Considered a Degenerative Disease?

Rheumatoid arthritis (RA) is often considered a degenerative disease due to its chronic nature and the impact it has on joint health over time. Initially, the disease presents with inflammation in the joints, which is primarily driven by the immune system erroneously attacking the synovial membrane. This immune response leads to the production of inflammatory cytokines, such as IL-1, IL-6, and TNF-α, which result in swelling, pain, and stiffness.

As the disease progresses, the persistent inflammation causes damage to the cartilage and underlying bone of the joints. This damage manifests as:

  • Increased wear and tear on joint structures.
  • Loss of cartilage leading to pain and decreased range of motion.
  • Formation of bone erosions due to the continuous inflammatory process.
These changes can substantially hinder a person's mobility and quality of life, emphasizing the degenerative characteristics of RA. Over time, individuals with RA often experience significant joint deterioration, which is distinct from conditions like osteoarthritis, where degeneration is more closely related to age and mechanical stress.

Therefore, the ongoing inflammation and damage caused by rheumatoid arthritis can classify it as a degenerative disease, leading to long-term disability without appropriate management.


Learn more about Rheumatoid Arthritis here:

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