Answer :
Final answer:
Ischemia occurs when MAP falls below 60 mm Hg for more than 25 minutes, leading to insufficient circulation and resulting in tissue hypoxia and potential cell death.
Explanation:
Ischemia is a condition characterized by restricted blood flow to tissues, causing a shortage of oxygen and nutrients needed for cellular metabolism. In considering mean arterial pressure (MAP), if the value falls below 60 mm Hg for an extended period, which is typically over 25 minutes, the pressure is not sufficient to ensure circulation through the tissues. This situation can lead to ischemia of the affected tissues. A commonly associated condition with ischemia is hypoxia, which is characterized by inadequate oxygenation of tissues, and if not quickly resolved, can result in cell death, especially in highly sensitive neurons.
