During clonal selection of T cells, which of the following accurately describes the fate of T cells that recognize foreign antigens presented by antigen-presenting cells (APCs)?

Select one:

A. T cells with high affinity for foreign antigens undergo clonal deletion to prevent autoimmunity.

B. T cells with moderate affinity for foreign antigens are induced into anergy to maintain tolerance.

C. T cells with high affinity for foreign antigens undergo clonal expansion and differentiation into effector T cells.

D. T cells with low affinity for foreign antigens are activated and differentiate into memory T cells.

T cells that recognize foreign antigens presented by APCs, specifically those with high affinity, undergo clonal expansion and differentiate into effector T cells. This process is crucial for an effective immune response. T cells with lower affinities may not effectively activate or differentiate.

Explanation:

Understanding T Cell Clonal Selection

During the process of clonal selection of T cells, those T cells that recognize foreign antigens presented by antigen-presenting cells (APCs) undergo a series of outcomes based on their affinity for the antigens.

Fate of T Cells Based on Antigen Affinity

The correct statement reflects that:

T cells with high affinity for foreign antigens undergo clonal expansion and differentiate into effector T cells. This means they proliferate and become activated to perform functions such as killing infected cells or helping other immune cells.

This expansion allows for an effective immune response against pathogens. Conversely, T cells with lower affinities may not be activated effectively, while those with very high affinities that also recognize self-antigens may indeed undergo deletion to prevent autoimmunity.

In conclusion, the correct choice regarding the fate of T cells is that high affinity T cells are the ones that proliferate into effector T cells.

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