Answer :
Final answer:
To determine the mL/hr rate for amphotericin B infusion for a 93 kg patient at 0.8 mg/kg/day, the calculation shows it should be 31 mL/hr, which doesn't match any of the provided answer choices.
Explanation:
The question involves calculating the appropriate rate for a continuous intravenous (IV) infusion of amphotericin B for a patient weighing 93 kg, prescribed at a dosage of 0.8 mg/kg/day. This medication has been diluted to a concentration of 0.1 mg/mL. To find the rate in mL/hr needed to deliver the daily dose, we first calculate the total daily dose in mg, then convert this into mL based on the medication concentration, and finally determine the hourly rate by dividing this total volume by 24 hours.
Calculation:
- Total daily dose: 0.8 mg/kg/day × 93 kg = 74.4 mg/day.
- Total volume of solution needed to deliver 74.4 mg at 0.1 mg/mL = 74.4 mg ÷ 0.1 mg/mL = 744 mL.
- Hourly infusion rate: 744 mL ÷ 24 hours = 31 mL/hr.
However, none of the provided options (a) 7, (b) 8, (c) 9, (d) 10 correspond to the calculated rate of 31 mL/hr. Therefore, it seems there might have been a misunderstanding or a mistake in the question or the options provided.
