Answer :
A bacterial strain exhibiting a mutation on the A site of a ribosome are most likely to resist the activity of antibiotics that target protein synthesis, specifically the class of antibiotics known as macrolides.
Macrolides work by binding to the A site on the ribosome and preventing elongation of the growing polypeptide chain. By binding to the A site, macrolides prevent translocation of the ribosome, halting protein synthesis and ultimately leading to bacterial cell death.
However, bacterial strains with mutations on the A site of ribosomes may have altered the shape or conformation of the ribosome, making it difficult for macrolides to bind and interfere with protein synthesis. As a result, these bacterial strains may exhibit resistance to macrolides.
It is important to note that there are other classes of antibiotics that target protein synthesis, such as tetracyclines and aminoglycosides, which may also be affected by mutations on the A site of ribosomes. Therefore, further testing and analysis would be needed to determine the specific class of antibiotics that the bacterial strain is resistant to.
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